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New Duo Potent Antibodies May Assist In HIV Vaccine Search

Submitted by on September 8, 2009 – 9:15 amNo Comment




Scientists piloted by the IAVI or International Aids Vaccine Initiative have stated that two antibodies to HIV have been discovered with a potential to target the vulnerable aspect of the virus’s defence mechanism, that may assist in the creation of the much needed HIV vaccine.

This is the first form of identification of such antibodies to have taken place in more than ten years, and has been the foremost one to have been obtained by isolation from donors hailing from developing countries.

The meticulous details regarding the breakthrough have been published in the journal Science. The scientists are optimistic that this discovery would be the harbinger to further analogous findings that would help in the global search of an effectual HIV vaccine.

Mr. Wayne Koff from IAVI elucidated that the novel antibodies uncovered are largely defusing antibodies that are produced by a small populace of HIV infected individuals. They are unique in comparison to several antibodies to HIV due to their high neutralisation percentage on the varied global HIV forms.

A prevalent belief was that for HIV prevention, a vaccine would be mandatory in order to gear the body into producing those potent antibodies prior to being exposed to the virus. Though, trials on animals have indicated that theoretically this form of vaccine might be effectual.

Prior to this discovery, merely four antibodies to HIV were detected that were concurred to have broad-ranging neutralisation effect. But the four antibodies functioned similarly by trussing to a place on HIV which was established to be tricky for the vaccine manufacturers to take advantage of.

The newest two antibodies have greater combat potential as they attach to the virus at places that the researchers consider to have greater accessibility. Theoretically, this would make it simpler to manufacture a vaccine that would encourage the body to begin creating those crucial antibodies. Due to the potency of these antibodies, a huge production would not be necessary to ensure protection.

The duo novel antibodies have been observed to attack one of those proteins which are used in the spike formation that are employed by HIV to spread infection in the cells. The exceedingly changeable nature of these proteins creates a major hurdle for the immune system to launch an attack. However, the latest antibodies have target-specific action on the particular area of one protein that is not changeable.

The experts have stated that HIV vaccine research would be continual endeavour and one must not over-anticipate that such discoveries would lead to a vaccine within some years as immense additional effort is needed on the research work to be able to create a vaccine that could undergo clinical tests.

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