How To Treat Bunions
March 29, 2013 – 12:00 am | No Comment
A bunion is a deformity that is mainly made up of a lateral deviation of the great toe which enlarges due to a tissue or a bone. It is a serious foot problem. These are formed within the foot and not on the surface of the foot. An arthritic condition and  a result of bone degeneration it is found as  a lump on the outside portion of the big toe. Bunions are seen near the joint of the toe and sometimes  [...]

Read the full story »

Home » Health News

A Promising Vaccine For Quitting The Horrendous Smoking Habit For Good

Submitted by on November 9, 2009 – 3:43 am3 Comments



All of us might be aware of someone around us who has perennially been attempting to quit smoking. All the available options to help smoke cessation like patches, gums, group therapy sessions and also exercise routines tailored to assist one in curbing those yearnings for a fag simply fail to work. Often people endeavouring to quit smoking go to all extents like smoking fake cigarettes, to countless pleading with those around them to discard off any cigarette packs if seen –however to no avail. Though these individuals do manage to stay smoke-free for few periods during their lifetime, they truly fail to let go of the habit, finding it incredibly tough to break out of the vicious smoking cycle.

Drug experts point out that nicotine is increasingly tougher to let go as compared to even heroin. The American Cancer Society has revealed alarming statistics which state that from the forty-four million individuals in the United States that smoked, nearly seventy percent acknowledged that they desired to quit and nearly forty percent did manage to refrain from smoking each year. However, just 4-7% truly stopped smoking without any assistance and as a life-long commitment.

But, lately there is ray of hope for such individuals. The National Institute on Drug Abuse – a branch of the National Institutes of Health, has offered a ten million dollars grant to Nabi Biopharmaceuticals to carry forward their anti-nicotine vaccine to the third phase of human research trials over the span of the subsequent couple of months. Named as ‘NicVAX’ –the vaccine functions by stimulating the immune system to produce antibodies which fasten themselves on to the nicotine that is present in the smoker’s system and essentially block the nicotine from ever reaching the brain.

Hence as a person smokes a cigarette, the nicotine is taken in via the lung tissue, inside the bloodstream and transported throughout the body. As nicotine is a miniscule particle, it could effortlessly pass the blood brain barricade and reach inside the brain. The nicotine then attaches to the receptors present in the brain, that start releasing dopamine – a kind of stimulant that offers a smoker a gratifying feeling called as the ‘smoker’s high’.

This process takes place so swiftly within the body – nearly lesser than a minute’s time subsequent to the inhalation of the tobacco smoke – hence the nicotine fix is speedy - the reason leading to addiction.

The NicVAX vaccine produces antibodies that cling to the nicotine present in the bloodstream and blocks it from passing over and reaching inside the brain via the brain-blood barricade. Due to the large size molecules of the nicotine-specific antibodies, they are unable to cross the barrier and reach the brain. As the attached nicotine is entrapped in the blood, it fails to get to the receptors that elicit the production of dopamine – that creates the gratifying response.

It is considered that the addictiveness of the smoker to nicotine would eventually ebb as the antibodies produced by Nic VAX continually binds to the nicotine, hence the extent of nicotine being able to reach the brain would eventually diminish.

Nabi has revealed that the third phase of the human trials would start by the concluding part of the year. The company states that till date, the outcomes have shown immense potential with negligible side effects. In the reports based on the second phase of the trials, Nabi has stated that a figuratively major number of candidates that were administered the NicVAX optimal dose managed to stop smoking and remained sober over lengthy periods of time – they were almost 3 times more likely to stay abstemious as compared to those who received the placebo. Additionally those candidates that persisted with their smoking habit exhibited an elevated antibody response to the NicVAX vaccine and have majorly lowered their smoking over the entire one year time period from about twenty cigarettes daily to ten cigarettes daily.

The testing for this vaccine would be conducted over a six-monthly time period with candidates being administered the vaccine in time interval of a month’s time. The antibodies were expected to last in the system for an extended time period. The researchers are still unclear just how long the antibodies would remain in the system.

Trial locations would be placed throughout the country and one could confirm the necessary details regarding the same on the website ‘clinicaltrials.gov’ in case one desires to be a candidate for the same.

However the vital query that lingers is ‘Will one be keen to get vaccinated on a periodic basis in order to aid one in quitting the habit?’

Related Posts with Thumbnails

Popularity: 10% [?]

3 Comments »

Leave a comment!

Add your comment below, or trackback from your own site. You can also subscribe to these comments via RSS.

Be nice. Keep it clean. Stay on topic. No spam.

You can use these tags:
<a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>

This is a Gravatar-enabled weblog. To get your own globally-recognized-avatar, please register at Gravatar.

CommentLuv badge